●Custom production As you want it
- Our organic synthesis business has started in operation since the 1980s,and we are one of the leading organic synthesis manufacturers in Japan.
We have acquired various technologies with over 30 years of experience in this field. (See Core Technology tab) - We plan the synthesis method according to your request and promise the benefit of our experience, skills, and suggestions assist you. In addition, we investigate literature when necessary, and are increasing the certainty for manufacturing.
- We consistently consider manufacturing plan, including scale-up and manufacturing at plant. We can accurately reflect customer’s request, and manufacture at short period.
- We have excellent facilities and systems corresponding to Labo, pilot scale,and mass production volume. (Commercial-based production started at 1988.)
As our facilities have a clean room, we can manufacture drug substance and pharmaceutical intermediates under the GMP. - Various analysis instruments are available, such as NMR, GC-MS, LC-MS, ICP etc., for qualitative and quantitative measurements.
●Equipments
Many reactors from 50 liters to 10,000 liters can efficiently scale up the reaction with full zone* type in reactors.
OSP [Multi Plant]
| Reactor | Relating Equipments |
|---|---|
| 500GL×2*（One reactor is autoclave) | GL Filter×2 |
| 500L GL×2（One reactor can use activated carbon treatment） | Vacuum Tray Decompression Dryer |
| 300L GL×1* | 50L Evaporator |
| 100L GL(Autoclave)×1* | |
| 50L GL×1* |
OS-2 [Multi Plant for GMP]
| Reactor | Relating Equipments |
|---|---|
| 6.0㎥GL×1* | Centrifuge×2 |
| 3.0㎥GL×1* | GL Filter×2 |
| 2.0㎥GL×2* | GL Filter（Setting in Clean room） |
| 2.0㎥GL×2 | Vacuum Tray Decompression Dryer×1 (Setting in Clean room) |
| 1.0㎥GL×2* | |
| 500L GL×1* | |
| 500L GL×1 | |
| 300L GL×1* |
OS-3 [Multi Plant for GMP]
| Reactor | Relating Equipments |
|---|---|
| 10.0㎥GL×2 * | Centrifuge |
| 6.0㎥GL×2 | GL Pressure Filter |
| 4.7㎥GL×1 | SV Dryer |
| Some Service Tanks | Vibrating Dryer |
※The production line（Crystallization→Centrifugal Separation→Drying→Packing in clean room) can correspond with GMP.
FP [Multi Plant for chemical products]
| Reactor | Relating Equipments |
|---|---|
| 3.0㎥GL×2 * | Centrifuge |
| 6.0㎥SUS×2 | Pressure Filter |
| 3.0㎥SUS×3 | |
| 2.0㎥SUS×1 |
FR [Multi Plant for chemical products]
| Reactor | Relating Equipments |
|---|---|
| 4.0㎥GL×2 * | Centrifuge |
| 3.0㎥GL×2 | GL Pressure Filter |
| 2.0㎥GL×1 | |
| 2.0㎥GL(Autoclave)×1* | |
| 1.0㎥GL×1* | |
| 3.0㎥SUS×1 |
Other Equipments [Drying Equipments]
| Vacuum Tray Decompression Dryer×2 |
| Conical Dryer 1.0㎥GL×2 |
| Conical Dryer 2.0㎥GL×1 |
| SV Dryer 2.0㎥ SUS |
*: The "full zone"stirrer
"Full zone" is the trade name of Kobelco Eco-Solutions Co,.Ltd.
http://www.kobelco-eco.co.jp/●Analytical instruments
| Structure analysis, Qualitative and Quantitative analysis |
|---|
| GC |
| HPLC |
| GC-MS |
| LC-MS |
| GPC |
| Ion chromatography |
| FT-IR |
| UV-Vis spectrophotometer |
| NMR |
| ICP-AES |
| Atomic absorption spectrophotometer |
| Total organic carbon analyzer |
| Polarimeter |
| X-ray fluorescence spectrometer |
| Karl Fisher Moisture titrator |
| Potentiometric titrator |
| Automatic melting-point meter |
| Color-difference meter |
| Differential scanning calorimeter |
| Thermogravimetry / Differential thermal analyzer |
| SEM-EDX |
| Microscope |
| Laser scattering particle size analyzer |
Fine Chemical products
| Structure | Information | CAS No. |
|---|---|---|
|
Name： Diphenyl phosphoryl Azide Abbreviation： DPPA N.M.： 275.19 |
26386-88-9 |
|
Name： 4-Acetamidobenzenesulfonyl Azide Abbreviation： ABSA N.M.： 204.24 |
2158-14-7 |
|
Name： Trimethylsilyl Azide Abbreviation： TMSA N.M.： 115.21 |
4648-54-8 |
|
Name： Kinds of 2-Mercaptobenzoxazole Abbreviation： N.M.： |
|
|
Name： Kinds of 2-Mercaptobenzothiazole Abbreviation： N.M.： |
|
|
Name： m-fluoro isothiocyanate Abbreviation： MFIT N.M.： 153 |
